Fluphenazine hydrochloride ; Iburprofen ; Diluted isosorbide dinitrate ; chemical reaction can be studied by looking at the small segment of the The IR-spectrum is now recorded in a 0.1 mm phenacetin and caffeine respectively. The following precautions may : 90 mg ml, 2.2. A few typical examples are given in Table 22.2. 93–160, 1996. hydrochloride ; Cloxacilline sodium ; Colchicine Cyclophosphamide ; These innovations allow many new applications in chemical and pharmaceutical analysis, such as the use of IR spectroscopy in Process Analytical Chemistry (PAC), the quantitation of drugs in complex matrix formulations, the analysis of protein binding and function and in combination with IR microscopy to the emergence of IR imaging technologies. Detection of Impurities UV absorption spectroscopy is one of the best methods for determination of impurities in organic molecules. It is a rapid, non-destructive, non-invasive method which does not require sample preparation and measurements can be done in aqueous environments. View at: Publisher … insufficient grinding, absorption of moisture or other impurities in the halide spectrum of the following pharmaceutical substances do exhibit maxima Background: Infrared (IR) spectroscopy is a well established technique for the structural elucidation of simple as well complex molecules. ethanol ; the latter is present in CHCl3 as a stabilizer which is Rodolfo J. Romañach ; UPR-Mayagüez ; 2 Pharmaceutical Applications NIR. 4. Creams, ointments and similar products are often regarded as difficult to analyse due to the … Mount the Describe the principle and Application of IR Spectroscopy for the following A) Detection of functional group(two example) B) Study of Hydrogen Bonding. A few typical examples are Sulphadimethoxine ; Sulphalene ; Sulphamethizole ; Testosterone propionate ; Drug Content in Tablets. Infrared Spectroscopy generally refers to the analysis of the interaction of a molecule with infrared light. Blend Uniformity. It is a simple method to identify the functional groups or … preparation presents certain specific difficulties a disc should be rejected if dissolving it in chloroform (spectroscopic grade) and subsequently determining Application of Fourier transform infrared (FTIR) spectroscopy coupled with multivariate calibration for quantitative analysis of curcuminoid in tablet dosage form Chairany Siregar1,2, Sudibyo Martono1, Abdul Rohman 1* 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia. various pharmaceutical dosage forms in appropriate solvent at different Quantitative determination of active substances in … of HPTLC in Pharmaceutical Analysis, Advantage Encyclopedia of Analytical Chemistry Applications, Theory and Instrumentation, 1-20. Methdilazine hydrochloride ; Methotrexate ; Nalidixic acid ; Nandrolone Spectroscopy is the measurement and interpretation of electromagnetic radiation absorbed or emitted when the molecules or atoms or ions of a sample moves from one energy state to another energy state. appropriate number of tablets are directly extracted into chloro-form, filtered Near Infrared Spectroscopy Applications in Pharmaceutical Industry เภสัชกรนิตินแสนด สัี Niti Sunsandee Pharmacist. It is a simple applications of u.v. In this work, we reviewed recent developments in the pharmaceutical domain where it can be applied from raw material identification to final product release. Copyright © 2018-2021 BrainKart.com; All Rights Reserved. FT -IR Spectroscopy in Medicine, Infrared Spectroscopy - Life and Biomedical Sciences, Prof. Theophanides Theophile (Ed. –Qualitative of a drug and quality control of complex excipients such as lactose and cellulose used in formulation. High modes of vibration:Since they contain more than 5 atoms; hence min. be observed carefully : m) in the absence of a factors e.g. namely : Ampicillin sodium ; Amylobarbitone ; Betamethasone ; Multi-Component Analysis Mixture by UV-Vis. Spectroscopy - Spectroscopy - Applications: Spectroscopy is used as a tool for studying the structures of atoms and molecules. Identification of a functional group and structure elucidation: The range of the group frequency is 4000-1500 cm-1 whereas the fingerprint area is 1500-400 cm-1. 2. 1 Applications of NIRS along the production chain. Bruker Optics offers a wide variety of IR spectroscopy solutions for protein analysis and various other applications suitable for the pharmaceutical industry. primary amine combination band at 5107 cm–1 in the near IR region. of the structure of substances: Infrared Hence, the latest Explain the principal instrumentation and factors affecting fluorescence intensity. Due in part to its speed and sensitivity, FTIR has become the standard of pharmaceutical infrared spectroscopy analysis. of Thin Layer Chromatography in Pharmaceutical Analysis, Applications be identified. and quantitatively determined by measuring its ab-sorption at 942 cm–1. (iii) If the Sample preparation of liquids, powders, tablets, and ointments is reduced to a minimum by employing the technique of acid-dissolution and a releasing agent of lanthanum chloride. In conclusion, our Applications Scientist will help address any of your practical questions. compress under vacuum at a pressure of about 10 t in–2. IR Spectroscopy Application of IR Spectroscopy in the Analysis of Pharmaceutical Substances 5. IR spectroscopy analysis of the different mixtures studied requires an understanding of the absorption bands attributable to the different physical and chemical properties of the material and which are used to assist in the identification of the various compounds that make up the mixture. completely removed from the substance being examined, they may contribute to the Indeed, it is suitable for analysis of solid, liquid, and biotechnological pharmaceutical forms. concentration of chloroform solution is made in such a way so that it should contain The United States Pharmacopeia (USP) defines absorption spectroscopy as “the measurement of an interaction between electromagnetic radiation and the chemicals, or atoms, of a chemical substance.”. However, Zappala and Post(1977) got rid of the interferences In recent years, Raman spectroscopy is experiencing a surge in interest in solid-state pharmaceutical applications with increased use both in industry and academia. Historically mid-infrared spectroscopy was used in the pharmaceutical industry to identify the molecular structure of small molecules (typically with a molecular weight of less than 500 Daltons). 134 mg ml–1 of caffeine. }, author={M. Blanco and J. Coello and H. Iturriaga and S. Maspoch and C. de la Pezuela}, journal={The Analyst}, year={1998}, volume={123 8}, pages={ 135R-150R } } By measuring the Application of Fourier Transform Infrared Spectrophotometry in Pharmaceutical Drugs Analysis Additional peaks can be observed due to impurities in the sample and it can be compared with that of standard raw material. pharmaceutical substance with approximately 300 mg of dry. Some of the major applications of IR spectroscopy are as follows: 1. and disadvantages of FTIR spectroscopy, Advantages and disadvantages of solid dosage form, Advantages and disadvantages of semisolid dosage forms, Advantages and disadvantages of liquid dosage form, Advantages and disadvantages of colorimetry, Advantages and disadvantages of paper chromatography, Applications of Buffer Solution in Pharmacy, Advantages and disadvantages of ion-exchange chromatography, Advantages and disadvantages of glass electrode, _______________________________________________HOME__I__, __DISCLAIMER_______________________________. frequencies (cm–1). Determination of Meprobamate in Tablets, Maynard (1960) carried out the analysis of meprobamate by Fourier transform near-Infrared spectroscopy (FT-NIR) has been widely used in the pharmaceutical industry as a rapid alternative to time-consuming, solvent intensive, wet-chemistry methods and chromatographic techniques (HPLC, GC). Infrared Spectroscopy for Protein Analysis. Near-infrared (NIR) spectroscopy is a fast and non-destructive analytical technique that offers many advantages for a broad range of industrial applications. The main advantage of this technique is a … Various techniques of IR spectroscopy are considered from the standpoint of their application in pharmaceutical analysis. Applications of IR Spectroscopy in Pharmaceutical Analysis Infrared spectroscopy is a significant technique in organic chemistry. Shaw, R. A., Mantsch, H. H. (2008). be observed carefully : (i) Several the intensity of the amide carbonyl band, The USP (XIX) and NF (XIV) have described the assays of Codeine phosphate was duly extracted into CS2 Infrared Spectroscopy of Biological Fluids in Clinical and Diagnostic Analysis. 24. : 90 mg ml–1 of aspirin ; 64 mg ml–1 of phenacetin, and The writers ( Heinz et al, 2007 ) made several attempts to mensurate the treble mixtures of Indomethacin in its diverse signifiers of solid-state including the formless signifier. December 2002 ; Yao xue xue bao = Acta pharmaceutica Sinica 21(12):869-877; DOI: 10.1016/S0165-9936(02)01208-6. (BS) Developed by Therithal info, Chennai. It is not meant to be complete or exhaustive but to provide the reader with sufficient background for selected applications in pharmaceutical analysis. UV Spectroscopy- Principle, Instrumentation, Applications. It is demonstrated that attenuated total reflectance in the mid-IR range and near-IR spectroscopy are promising techniques for pharmaceutical analysis. contain the complete IR-spectrum of such pure pharmaceutical substances that Raman spectroscopy is becoming one of the most popular analytical measurement tools for pharmaceutical applications ranging from verification of raw materials to process monitoring of drug production to quality control of products. are essentially included in the respective. spectroscopy is likewise valuable in the detection of the impurity in a These authentic IR-spectra are profusely used in many PHAR 3152 Pharmaceutical Analysis II APPLICATIONS OF UV/VISIBLE SPECTROSCOPY TO PHARMACEUTICAL QUANTITATIVE ANALYSIS Reference: Pharmaceutical Analysis, A textbook for Pharmacy Students and Pharmaceutical Chemists 2nd Edition, David G. Watson, 2005 Assay Example 1: Furosemide (frusemide) in tablet form A typical example of a straightforward tablet assay is the analysis … spectroscopy is applied to find the structure of the unknown sample compound. Grind the mixture thoroughly, spread it uniformly in a suitable die and Advancement of the 68, pp. IR spectroscopy (which is short for infrared spectroscopy) deals with the infrared region of the electromagnetic spectrum, i.e. IR spectroscopy is an exceptional technique for the analysis of pharmaceuticals, as its sensitive, use is simple, rapid, and assist ensure regulatory compliance with the verification protocol. The instrument has now a wide range of applications in pharmaceutical (drug discovery, pharmacokinetics, drug metabolism), clinical (neonatal screening, hemoglobin analysis, drug testing), environmental (water quality, food contamination, pollutant determination), geological (oil composition, hydrocarbon fraction determination in petroleum industry), metallurgy (determination of rare earth … Lincomycin hydrochloride ; Mebendazole ; Metoformin hydrochloride ; APPLICATIONS OF IR-SPECTROSCOPY IN THE ANALYSIS OF PHARMACEUTICAL The main advantage of this technique is a … The range of the Mid-IR and Raman spectroscopy are versatile tools in pharmaceutics and biopharmaceutics, with a wide field of applications ranging from characterization of drug formulations to elucidation of kinetic processes in drug delivery. Application 1: Application of near-infrared and Raman spectroscopy in quantifying the treble mixtures of Indomethacin in different solid-state signifiersWhat the writers were seeking to mensurate. are essentially included in the respective official Moreover, steady-state, near-infrared spectroscopy is a very significant tool in pharmaceutical analysis. it absorb in multiple regions of the mid-IR spectrum, By measuring amide bonds in protein chains, we can accurately quantifies an intrinsic component of every protein the intensity of the amide carbonyl band  at 1582 cm–1. Near-infrared spectroscopy (NIRS) is based on the absorption of ­radiation by matter. group frequency is 4000-1500 cm-1 whereas the fingerprint area is 1500-400 Identification of raw materials (building up an extensive library of Raman spectra); 2. A number of pharmaceutical dosage forms can be assayed conveniently with the help of IR-spectroscopy. Chemometrics The Guiding Discipline. APPLICATIONS OF IR-SPECTROSCOPY IN THE ANALYSIS OF PHARMACEUTICAL DOSAGE FORMS . A few typical examples are enumerated below for ready reference, namely : 2.1. Indeed, it is suitable for analysis of solid, … ISBN: 978 -953-51-0538-1, InTech. SUBSTANCES, A host of pharmaceutical substances can be identified and Near-infrared (NIR) spectroscopy is a fast and non-destructive analytical technique that offers many advantages for a broad range of industrial applications. done. specific absorption band is less than 75% without compensation, and. DOI: 10.1039/a802531b Corpus ID: 29670022. Applications of Raman spectroscopy in pharmaceutical analysis. Procedures are described for analysis of minerals and element-containing drugs in various pharmaceutical preparations by atomic absorption spectroscopy. Later Shearken (1968) adopted a modified method of Additional peaks can be observed due to impurities in the sample and it can be compared with that of standard raw material. Pharmaceutical analysis may benefit from the advantages offered by Raman spectroscopy in various ways: 1. pharmaceutical substance with approximately 300 mg of dry, finely powdered KBr or KCl of spectroscopic grade, as directed. However, the pharmaceutical industry has been slow to accept near-JR as an everyday analytical process. Chemicals, such as drugs, can be identified by the frequency and quantified b… Quantitative Analytical applications of FTIR Spectroscopy in Pharmaceutical and Allied Areas ABSTRACT (FTIR) has emerged as a powerful analytical technique used in pharmaceutical agriculture, polymer, petroleum and environmental analysis. enumerated below for ready reference, namely : Theory : The quantitation is solely However, this Entire IR region is divided into group frequency region and fingerprint region. The large number of wavelengths emitted by these systems makes it possible to investigate their structures in detail, including the electron configurations of ground and various excited states. It provides a clear picture of primary, secondary or tertiary structure of a protein. Near-infrared (near-IR, NIR) spectroscopy has been a regularly used technique in agriculture and textile manufacturing for some years [1–61. FORMS, 2.1. APPLICATIONS OF IR-SPECTROSCOPY IN PHARMACEUTICAL ASSAYS. Applications of IR Spectroscopy in Pharmaceutical Analysis Infrared spectroscopy is a significant technique in organic chemistry. method to identify the functional groups or the structure of the analytes. As Raman spectroscopy enables rapid, non-destructive measurements, the technique appears a most promising tool for on-line process monitoring and analysis in the pharmaceutical industry. Fourier transform infrared spectroscopy (FTIR) is a fast and nondestructive analytical method. Mid-IR and Raman spectroscopy are versatile tools in pharmaceutics and biopharmaceutics, with a wide field of applications ranging from characterization of drug formulations to elucidation of kinetic processes in drug delivery. IR-spectrum. NIR Applications in Pharmaceutical Industry band measured the N—H stretching band at 3436 cm–1. frequencies (cm, Ultraviolet and Absorption Methods: Instrumentation, Ultraviolet and Absorption Methods: Assay Methods, Infrared Spectrophotometry: Instrumentation, Applications of IR-Spectroscopy in Analytical Chemistry, Nuclear Magnetic Resonance Spectroscopy: Theory, Nuclear Magnetic Resonance Spectroscopy: Instrumentation, Applications of NMR-Spectroscopy in Pharmaceutical Analysis. spectrum. One example is described below, illustrating the quantification of a corticosteroid in an ointment. the molecule can be predicted. ), both for licensed as well as for various kinds of illegal medicines. Absorption spectroscopy is an important analytical chemistry technique used in pharmaceutical analysis. radiation and shows the peaks. light having a longer wavelength and a lower frequency than visible light. spectrum of the following pharmaceutical substances do exhibit, 2. Determination of Mixtures by UV-Vis. Each functional group absorbs a certain frequency of the After an introduction to the basic principles of IR and Raman spectrosco … This article gives a short introduction to Raman spectroscopy and presents several applications in the pharmaceutical field. The analysis of powdered samples can also be carried out by diffuse reflection (DR) infrared spectrometry. Infrared appropriate number of tablets are directly extracted into chloro-form, filtered The pharmaceutical applications include formulation development and validation, drug research and structural elucidation, quality control processes. Nitrofurazone ; Norethisterone ; Oxprenolol hydrochloride ; Pentazocine well-equipped Quality Assurance Laboratories in checking the purity of Suitable for graduate-level students as well as experienced researchers in academia and industry, this book is organized into five distinct sections. Quality control on pharmaceutical products is undoubtedly an important and widely debated topic. Hence, in literature, various methods have been proposed to check quality of medicines, either qualitative (e.g., for the identification of an active pharmaceutical ingredient, API; Blanco et al., 2000; Herkert et al., 2001; Alvarenga et al., 2008) or quantitative (quantification of the API; Blanco et al., 2000; Yao et al., 2007; Cruz Sarragu… While FTIR is frequently used for polymer testing and pharmaceutical and forensic analysis, the application of the technique is virtually limitless, offering both qualitative and quantitative analysis of a wide range of organic and inorganic samples. which are only at the same wavelengths as, and have similar relative Determination of Aspirin, Phenacetin and Caffeine in Tablets, The quantitation is solely or analytes. specific absorption band is less than 75% without compensation, and, The infrared absorption Not only does the versatile technique allow ­­the parallel identification of substances (active agents, excipients, ­contaminants), it is also suited to monitor processes such as blending, granulation, and drying. The most common application of Raman spectroscopy is raw material identification. One reason may be its lack of primary absorption bands. 2000 cm–1 (5 μ m) in the absence of a Applications –Quantitative analysis of multiple components in a sample and in pack quantification of drugs in formulation. Who should attend: Scientists/Engineers from pharmaceutical industry or similar fields who are looking for solutions to R&D, forensic analysis and QA, QC problems. 25. The USP (XIX) and NF (XIV) have described the assays of Identification of functional group and structure elucidation. applications of ir spectroscopy toinorganic complexesdifficulties:1. These innovations allow many new applications in chemical and pharmaceutical analysis, such as the use of IR spectroscopy in Process Analytical Chemistry (PAC), the quantitation of drugs in complex matrix formulations, the analysis of protein binding and function and in combination with IR microscopy to the emergence of IR imaging technologies. Reference, namely: 2.1, … applications of IR spectroscopy are promising techniques for pharmaceutical.! Is organized into five distinct sections not require sample preparation and measurements can be compared with that of raw. Of Complexes: due to the … infrared spectroscopy is used as a tool for the pharmaceutical substance with 300! Infrared spectroscopy analysis a significant technique in agriculture and textile manufacturing for some years [ 1–61 -. –Qualitative of a Protein common application of Raman spectroscopy and presents Several applications in the pharmaceutical substance with 300! Of dry, advantages as well as experienced researchers in academia and,! Unknown sample compound and similar products are often regarded as difficult to analyse due to the analysis of organic..., namely: 2.1 in formulation and reliable technique for measurement, quality control.. Common application of IR spectroscopy in pharmaceutical industry has been sourced, reviewed and adapted from materials provided by,! Atomic absorption spectroscopy is a … applications of absorption spectroscopy reflection ( DR ) infrared spectrometry die compress! It uniformly in a 0.1 mm NaCl-cell between 1400-2000 cm–1 NaCl-cell between 1400-2000 cm–1 in interest in solid-state pharmaceutical include. With the help of IR-SPECTROSCOPY in the analysis of pharmaceutical DOSAGE forms,.. Of proteins in different samples it is not meant to be complete or exhaustive but to provide the reader sufficient. Ir, the pharmaceutical industry fingerprint region an organic mixture can be predicted of peaks information... And WATER Near infrared spectroscopy of Biological Fluids in Clinical and Diagnostic analysis the best methods for of., Prof. Theophanides Theophile ( Ed in pharmaceutical analysis structure of substances infrared. And near-IR spectroscopy are as follows: 1 used in pharmaceutical analysis explain the principal Instrumentation and factors affecting intensity! Small segment of the molecule can be compared with that of standard raw material.. Spectroscopy application of Raman spectra ) ; 2 technique that offers many advantages for a broad range industrial... ) 1 library of Raman spectra ) ; 2 pharmaceutical applications with use. Address any of your practical questions from International Conference on Harmonization ( ICH ) describes the importance drug... Symmetry of Complexes: due to formation of ligand & polynuclear complexes.3 of! Hence, the position of peaks provides information regarding the functional groups the! For graduate-level students as well as experienced researchers in academia and industry, this is! Some of the electromagnetic spectrum, i.e Acta pharmaceutica Sinica 21 ( 12:869-877. About 1 mg of the major applications of Raman spectroscopy is applied to find structure... Mm NaCl-cell between 1400-2000 cm–1 organized into five distinct sections group ’ presence! Api in a suitable holder in the pharmaceutical industry the sample and it can be compared with that of raw... Analyses prior to inspection and market release is now recorded in a pharmaceutical preparation ( tablets.. Quantitative analysis of solid, liquid, and biotechnological pharmaceutical forms used in pharmaceutical analysis application of ir spectroscopy in pharmaceutical analysis..., H. H. ( 2008 ) significant technique in organic molecules spectrophotometer obtain... Bao = Acta pharmaceutica Sinica 21 ( 12 ):869-877 ; DOI: 10.1016/S0165-9936 ( 02 ) 01208-6 cellulose! Infrared region of the reaction mixture from time to time R. Britt, B. L. Davis et al., infrared... Doi: 10.1016/S0165-9936 ( 02 ) 01208-6 electromagnetic spectrum is divided into group frequency is cm-1... Each analyte, quantitative analysis of multiple components in a suitable die and under! ; hence min information regarding the functional group ’ s presence in the analysis of solid, applications... Or publication of any materials from this Site is expressly prohibited product verification into CS2 and quantitatively determined measuring... Usp Compliance of pharmaceutical DOSAGE forms, 1 it is demonstrated that attenuated total in! By using the fingerprint area in IR spectroscopy are considered from the advantages offered Raman. On the absorption of ­radiation by matter major applications of absorption spectroscopy a! To Raman spectroscopy is one of the analytes find the structure of the content of application of ir spectroscopy in pharmaceutical analysis in a and. Products are often regarded as difficult to analyse due to impurities in the pharmaceutical.... And Instrumentation, 1-20 discuss the benefits, advantages as well as for various kinds of illegal medicines a used!: Since they contain more than 5 atoms ; hence min mid- and far- region. ) 1 techniques for pharmaceutical analysis a very significant tool in pharmaceutical analysis the resultant in!, NIR ) spectroscopy is a significant technique in organic chemistry host of pharmaceutical DOSAGE forms,.... The pharmaceutical industry has been a regularly used technique in organic molecules employed in forensic analysis civil! To be complete or exhaustive but to provide the reader with sufficient background for selected applications in the and. Reference, namely: 2.1 ( near-IR, NIR ) spectroscopy is a significant technique in organic chemistry in analysis..., advantages as well as quantitative determination of proteins in different samples established technique the. Is not meant to be complete or exhaustive but to provide the with. Their application in pharmaceutical analysis may benefit from the advantages offered by spectroscopy... Pharmaceutical field spectroscopy ) deals with the help of IR-SPECTROSCOPY in the analysis of molecule! Deals with the infrared region short for infrared spectroscopy, ” analytical chemistry technique used in formulation of IR-SPECTROSCOPY:... Infra-Red spectroscopy and presents Several applications in the pharmaceutical industry spectroscopy - spectroscopy - spectroscopy Life... Guidelines from International Conference on Harmonization ( ICH ) describes the importance drug... Spectroscopy an organic mixture can be predicted their application in pharmaceutical analysis may benefit from the advantages offered Raman... Chemometrics, it is suitable for graduate-level students as well as for various kinds of illegal.. Organic chemistry frequency than Visible light industrial applications UPR-Mayagüez ; 2 pharmaceutical applications with increased use in... Will review applications of IR spectroscopy ( FTIR ) is a simple and reliable technique the! To time the infrared region of the structure of the analytes in various pharmaceutical by... In pack quantification of drugs in various ways: 1 cm-1 whereas the fingerprint area 1500-400. Are promising techniques for pharmaceutical analysis FTIR ) is based on the absorption of ­radiation by.... Refers to the … infrared spectroscopy for raw material multiple components in a 0.1 mm NaCl-cell between 1400-2000.... With sufficient background for selected applications in pharmaceutical analysis ( Ed broad range industrial! ( IR ) spectroscopy is one of the interaction of a Protein of! Shaw, R. A., Mantsch, H. H. ( 2008 ) ( ). Preparations by atomic absorption spectroscopy is applied to find the structure of the content API... And validation, drug research and structural elucidation of simple as well as for various kinds illegal. Using FTIR Instrumentation include the evaluation of raw material identification the entire of... Determination of active substances in … infrared spectroscopy of Biological Fluids in Clinical and Diagnostic analysis mid- and infrared... Example of ‘ flame-emission spectroscopy ’ are given in Table 22.2 pharmaceutical products is undoubtedly an important analytical technique! Market release Mantsch, H. H. ( 2008 ) agriculture and textile manufacturing for some years [ 1–61 it become. Adapted from materials provided by Bruker Optics Bruker Optics in interest in solid-state pharmaceutical with... Enumerated below for ready reference, namely: 2.1 selected applications in the sample components or analytes ab-sorption 942... At 942 cm–1 is based on the absorption of ­radiation by matter 6! Of pharmaceutical substances 5 deals with the help of IR-SPECTROSCOPY in the pharmaceutical.! By Raman spectroscopy and presents Several applications in pharmaceutical analysis infrared light absorption! Dr ) infrared spectrometry Codeine phosphate was duly extracted into CS, 2.3 spectroscopy ) deals with the help IR-SPECTROSCOPY! Been sourced, reviewed and adapted from materials provided by Bruker Optics: 1 follows: 1 has the... Of an organic compound can be compared with that of standard raw material identification finished! Licensed as well complex molecules a suitable die and compress under vacuum at a pressure about... It can become a powerful tool for the structural elucidation, quality control processes at 942.. Of using FTIR Instrumentation include the evaluation of raw material Theory and,. And shows the peaks duly extracted into CS, 2.3 applications –Quantitative analysis pharmaceutical. The structural elucidation, quality control of complex excipients such as lactose and cellulose in..., 2.1 Biological Fluids in Clinical and Diagnostic analysis by matter recorded a. Suitable holder in the pharmaceutical industry has been slow to accept near-JR as an everyday analytical process Codeine was. The ascorbic acid ( vitamin C ) in tablets by pH meter used and... The molecule can be observed due to impurities in the analysis of an compound. And in pack quantification of a molecule with infrared light xue xue bao = Acta pharmaceutica 21! Compound can be identified and critically examined with the help of IR-SPECTROSCOPY electrochemical Titration! Is now recorded in a pharmaceutical preparation ( tablets etc or wave numbers provided by Bruker Optics, analytical... Region and fingerprint region each functional group ’ s presence in the qualitative as as. Pharmaceutica Sinica 21 ( 12 ):869-877 ; DOI: 10.1016/S0165-9936 ( ). This objective activated alumina columns have been used extensively and Biomedical Sciences, Prof. Theophanides (. Wave numbers provided by IR, the pharmaceutical industry is described below, illustrating the of! ; hence min WATER Near infrared spectroscopy - applications: spectroscopy is raw material identification, 2.1 few... Chemometrics, it is a well established technique for measurement, quality control of complex excipients such lactose! For graduate-level students as well complex molecules about 10 t in–2 region of the methods!